Effect of Hydroalcoholic Leaves Extract of Ziziphora tenuior L. on Pain in Male Rats

Ziziphora tenuior is one of the traditional medicinal herbs; the main active chemical composition of this herb is an ingredient named as Pulegone which is known well for its anti-inflammatory and analgesic effects. Considering, the side effects of synthetic drugs, researcher’s attention has been attracted to the use of herbal medicines.In this study, after inducing ear edema via Xylenol, the anti-inflammatory activity of ethanol extracts on vascular permeability in (NMRI) rats was studied. 60 rats were divided into 6 groups of 10 as follows: Control (no treatment), sham (receiving physiological saline), groups 3, 4, and 5 treated with Ziziphora tenuior extracts which received doses of 20, 50 and 100 milligrams per kilogram of body weight, respectively, and groups 6 through 10 which received Dexamethasone at a concentration of 10 mg per kg of body weight in the amount of 0/2 milliliters. The results of the present study showed that intraperitoneal injection of Ziziphora tenuior extracts at doses of 50 and 100 mg per kg body weight, results in a significant decrease in inflammation induced via Xylenol in mature male rats (p≤ 0.05), as like lessening of inflammation via 10 mg body weight of Dexamethasone. Furthermore, the group receiving 100 milligrams per kilograms of Ziziphora tenuior extracts showed less inflammation compared to the group receiving dexamethasone. However, no significant difference was seen.Ziziphora tenuior extract dose-dependently decreases inflammation of ear edema test induced via Xylenol significantly. Probably, the presence of Flavonoids found in the herb, causes its anti-inflammatory effects